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After it had been shown that HMG-CoA reductase is overexpressed in human lung adenocarcinoma when compared with normal tissues, fluvastatin, an inhibitor of HMG-CoA reductase, suppressed NSCLC cell growth and induced apoptosis by inhibiting the HMG-CoA reductase-driven Braf/MEK/ERK1/2 and Akt signaling pathways

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Lanifibranor also significantly reduced ALT (26.1 U/L), AST (15.1 U/L), hsCRP (2.0 mg/L), HOMA-IR (5.8 units), HbA1c (0.4% points), and triglycerides (43.4 mg/dL)

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